| Enzyme name | Gamma-hexachlorocyclohexane dehydrochlorinase |
| Description | Catalyzes the conversion of the important environmental pollutant gamma-hexachlorocyclohexane (gamma-HCH or lindane) to 1,3,4,6-tetrachloro-1,4-cyclohexadiene (1,4-TCDN) via gamma-pentachlorocyclohexene (gamma-PCCH), proceeding by two successive 1,2-anti conformationally dependent dehydrochlorinations |
| Synonyms |
LinA dehydrochlorinase gamma-BHC dehydrochlorinase gamma-hexachlorocyclohexane dehydrochlorinase HCH dehydrochlorinase Lina2 gamma-HCH dehydrochlorinase |
| Degradation pathway |
Alpha-hexachlorocyclohexane degradation Beta-hexachlorocyclohexane degradation Delta-hexachlorocyclohexane degradation Gamma-hexachlorocyclohexane degradation |
| Reaction catalyzed by enzyme |
hexachlorocyclohexane <=> 1,3,4,5,6-pentachlorocyclohexene + HCl 1,3,4,5,6-pentachlorocyclohexene <=> 1,3,4,6-tetrachlorocyclohexa-1,4-diene + HCl |
| Enzyme class | Lyases |
| BRENDA | EC 4.5.1.B1 |
| KEGG Orthology ID | K15236 |
| expasy | EC 4.5.1.- |
| Enzyme Database | N/A |
| Organism |
Sphingobium japonicum Sphingobium japonicum |
| Status |
Reviewed Reviewed |
| Encoding gene | LinA |
| Gene cluster | LinABCDEFGHJ |
| subnit |
LinA LinA2 |
| Protein Name |
gamma-BHC dehydrochlorinase Hexachlorocyclohexane dehydrochlorinase 2 |
| GenBank ID |
D90355 AY150580 |
| Protein ID |
BAA14369.2 AAN64240.2 |
| UniProtKB ID |
P51697 P59767 |
| Author | Imai et al., 1991 |
| Title | Molecular cloning of a Pseudomonas paucimobilis gene encoding a 17-kilodalton polypeptide that eliminates HCl molecules from gamma-hexachlorocyclohexane. |
| PMID | 1718942.0 |
| Pubmed Link | Link |
| Research Link | Link |
| Author | Manickam et al., 2007 |
| Title | Isolation of hexachlorocyclohexane-degrading Sphingomonas sp. by dehalogenase assay and characterization of genes involved in ?-HCH degradation |
| PMID | 18042212.0 |
| Pubmed Link | Link |
| Research Link | Link |
| Author | Kumari et al., 2002 |
| Title | Cloning and Characterization of lin Genes Responsible for the Degradation of Hexachlorocyclohexane Isomers by Sphingomonas paucimobilis Strain B90 |
| PMID | 12450824.0 |
| Pubmed Link | Link |
| Research Link | Link |