| Enzyme name | 1,3,4,6-tetrachloro-1,4-cyclohexadiene hydrolase |
| Description | Catalyzes conversion of 1,3,4,6-tetrachloro-1,4-cyclohexadiene (1,4-TCDN) to 2,5-dichloro-2,5-cyclohexadiene-1,4-diol (2,5-DDOL) via the intermediate 2,4,5-trichloro-2,5-cyclohexadiene-1-ol (2,4,5-DNOL) |
| Synonyms |
1,3,4,6,-tetrachloro-1,4-cyclohexadiene halidohydrolase LinB 1-haloalkane dehalogenase Haloalkane dehalogenase 1-chlorohexane halidohydrolase |
| Degradation pathway |
Alpha-hexachlorocyclohexane degradation Beta-hexachlorocyclohexane degradation Delta-hexachlorocyclohexane degradation Gamma-hexachlorocyclohexane degradation |
| Reaction catalyzed by enzyme |
1,3,4,6-tetrachlorocyclohexa-1,4-diene (1,4-TCDN) + H2O <=> 2,4,5-trichloro-2,5-cyclohexadiene-1-diol (2,4,5-DNOL) + Chloride + Hydrogen ions |
| Enzyme class | Hydrolases |
| BRENDA | EC 3.8.1.5 |
| KEGG Orthology ID | K01563 |
| expasy | EC 3.8.1.5 |
| Enzyme Database | EC 3.8.1.5 |
| Organism |
Sphingobium japonicum |
| Status |
Reviewed |
| Encoding gene | LinB |
| Gene cluster | LinABCDEFGHJ |
| subnit |
LinB |
| Protein Name |
1,3,4,6-tetrachloro-1,4-cyclohexadiene hydrolase |
| GenBank ID |
D14594.2 |
| Protein ID |
BAA03443.2 |
| UniProtKB ID |
D4Z2G1 |
| Author | Nagata et al., 1993 |
| Title | Cloning and sequencing of a dehalogenase gene encoding an enzyme with hydrolase activity involved in the degradation of gamma-hexachlorocyclohexane in Pseudomonas paucimobilis |
| PMID | 7691794.0 |
| Pubmed Link | Link |
| Research Link | Link |
| Author | Manickam et al., 2007 |
| Title | Isolation of hexachlorocyclohexane-degrading Sphingomonas sp. by dehalogenase assay and characterization of genes involved in ?-HCH degradation |
| PMID | 18042212.0 |
| Pubmed Link | Link |
| Research Link | Link |
| Author | Kumari et al., 2002 |
| Title | Cloning and Characterization of lin Genes Responsible for the Degradation of Hexachlorocyclohexane Isomers by Sphingomonas paucimobilis Strain B90 |
| PMID | 12450824.0 |
| Pubmed Link | Link |
| Research Link | Link |
| Author | Kaminski et al., 2019 |
| Title | Genomic Analysis of ?-Hexachlorocyclohexane-Degrading Sphingopyxis lindanitolerans WS5A3p Strain in the Context of the Pangenome of Sphingopyxis |
| PMID | 31500174.0 |
| Pubmed Link | Link |
| Research Link | Link |