| Enzyme name | Biphenyl-2,3-diol 1,2-dioxygenase |
| Description | Catalyzes the meta-cleavage of the hydroxylated biphenyl ring. The enzyme can oxidize a wide range of substrates, and the substrate preference order is 2,3-dihydroxybiphenyl > 3-methylcatechol > catechol > 4-methylcatechol > 4-chlorocatechol. Shows a preference for catechols with groups immediately adjacent to the hydroxyl substituents. 1,1-Dichloro-2-(dihydroxy-4'-chlorophenyl)-2-(4'-chlorophenyl)ethylene; 3-[2,2-Dichloro-1-(4-chlorophenyl)vinyl]-6-chlorobenzene-1,2-diol; 2,3-Dihydroxy-DDE is converted to 6-Oxo-2-hydroxy-7-(4'-chlorophenyl)-3,8,8-trichloroocta-2E,4E,7E-trienoate. |
| Synonyms |
bphC 2,3-dihydroxybiphenyl dioxygenase (DHBD) 2,3-OHBP oxygenase EC 1.13.11.39 Biphenyl-2,3-diol-1,2 dioxygenase |
| Degradation pathway |
DDT degradation |
| Reaction catalyzed by enzyme |
biphenyl-2,3-diol + O2 <=> 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate |
| Enzyme class | Oxidoreductases |
| BRENDA | EC 1.13.11.39 |
| KEGG Orthology ID | K00462 |
| expasy | EC 1.13.11.39 |
| Enzyme Database | EC 1.13.11.39 |
| Organism |
Paraburkholderia xenovorans ( |
| Status |
Reviewed |
| Encoding gene | bphC |
| Gene cluster | bhpABCDEF |
| subnit |
bphC |
| Protein Name |
biphenyl-2,3-diol 1,2-dioxygenase |
| GenBank ID |
X66122.1 |
| Protein ID |
CAA46910.1 |
| UniProtKB ID |
P47228 |
| Author | Masai et al., 1995 |
| Title | Characterization of biphenyl catabolic genes of gram-positive polychlorinated biphenyl degrader Rhodococcus sp. strain RHA1 |
| PMID | 7793929.0 |
| Pubmed Link | Link |
| Research Link | Link |
| Author | Yamada et al., 1998 |
| Title | Two nearly identical aromatic compound hydrolase genes in a strong polychlorinated biphenyl degrader, Rhodococcus sp. strain RHA1 |
| PMID | 9603807.0 |
| Pubmed Link | Link |
| Research Link | Link |
| Author | Yang et al., 2007 |
| Title | Characterization and functional analysis of a novel gene cluster involved in biphenyl degradation in Rhodococcus sp. strain R04 |
| PMID | 18045404.0 |
| Pubmed Link | Link |
| Research Link | Link |
| Author | Masai et al., 1997 |
| Title | The bphDEF meta-cleavage pathway genes involved in biphenyl/polychlorinated biphenyl degradation are located on a linear plasmid and separated from the initial bphACB genes in Rhodococcus sp. strain RHA1 |
| PMID | 9073078.0 |
| Pubmed Link | Link |
| Research Link | Link |