| Enzyme name | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase (HOPDA hydrolase) |
| Description | Catalyzes an unusual C-C bond hydrolysis of 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid (HOPDA) to produce benzoic acid and 2-hydroxy-2,4-pentadienoic acid (HPD). |
| Synonyms |
2,6-dioxo-6-phenylhexa-3-enoate hydrolase EC 3.7.1.8 bhpD HOHPDA hydrolase 2,6-dioxo-6-phenylhexa-3-enoate benzoylhydrolase 2-hydroxy-6-oxo-6-(2-aminophenyl)hexa-2,4-dienoic acid hydrolase 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase 2-hydroxy-6-oxo-6-phenylhexa-2,4-dieonic acid hydrolase 6-phenyl HODA hydrolase |
| Degradation pathway |
DDT degradation |
| Reaction catalyzed by enzyme |
2,6-dioxo-6-phenylhexa-3-enoate + H2O <=> 2-oxopent-4-enoate + benzoate + H+ |
| Enzyme class | Hydrolases |
| BRENDA | EC 3.7.1.8 |
| KEGG Orthology ID | K10222 |
| expasy | EC 3.7.1.8 |
| Enzyme Database | EC 3.7.1.8 |
| Organism |
Paraburkholderia xenovorans |
| Status |
Reviewed |
| Encoding gene | bph |
| Gene cluster | bhpABCDEF |
| subnit |
bphD |
| Protein Name |
2,6-dioxo-6-phenylhexa-3-enoate hydrolase |
| GenBank ID |
X66123.1 |
| Protein ID |
CAA46911.1 |
| UniProtKB ID |
P47229 |
| Author | Hofer et al., 1993 |
| Title | Genetic analysis of a Pseudomonas locus encoding a pathway for biphenyl/polychlorinated biphenyl degradation |
| PMID | 8344527.0 |
| Pubmed Link | Link |
| Research Link | Link |
| Author | Masai et al., 1995 |
| Title | Characterization of biphenyl catabolic genes of gram-positive polychlorinated biphenyl degrader Rhodococcus sp. strain RHA1 |
| PMID | 7793929.0 |
| Pubmed Link | Link |
| Research Link | Link |
| Author | Yamada et al., 1998 |
| Title | Two nearly identical aromatic compound hydrolase genes in a strong polychlorinated biphenyl degrader, Rhodococcus sp. strain RHA1 |
| PMID | 9603807.0 |
| Pubmed Link | Link |
| Research Link | Link |
| Author | Yang et al., 2007 |
| Title | Characterization and functional analysis of a novel gene cluster involved in biphenyl degradation in Rhodococcus sp. strain R04 |
| PMID | 18045404.0 |
| Pubmed Link | Link |
| Research Link | Link |