| Enzyme name | 4-hydroxy-2-oxovalerate aldolase |
| Description | Catalyzes the retro-aldol cleavage of both 4-hydroxy-2-oxopentanoate (HOPA) and 4-hydroxy-2-oxohexanoate (HOHA) to pyruvate and acetaldehyde or propanaldehyde, respectively. |
| Synonyms |
4-hydroxy-2-oxopentanoate pyruvate-lyase (acetaldehyde-forming) (S)-4-hydroxy-2-oxopentanoate pyruvate-lyase (acetaldehyde-forming) 4-hydroxy-2-ketovalerate aldolase 4-hydroxy-2-oxopentanoate pyruvate-lyase |
| Degradation pathway |
DDT degradation |
| Reaction catalyzed by enzyme |
(S)-4-hydroxy-2-oxopentanoate <=> acetaldehyde + pyruvate |
| Enzyme class | Lyases |
| BRENDA | 4.1.3.39 |
| KEGG Orthology ID | EC 4.1.3.39 |
| expasy | EC 4.1.3.39 |
| Enzyme Database | EC 4.1.3.39 |
| Organism |
Paraburkholderia xenovorans |
| Status |
Reviewed |
| Encoding gene | bhp |
| Gene cluster | bhpABCDEF |
| subnit |
bhpF |
| Protein Name |
4-hydroxy-2-oxovalerate aldolase 4 |
| GenBank ID |
CP000272.1 |
| Protein ID |
ABE37049.1 |
| UniProtKB ID |
P51015 |
| Author | Masai et al., 1995 |
| Title | Characterization of biphenyl catabolic genes of gram-positive polychlorinated biphenyl degrader Rhodococcus sp. strain RHA1 |
| PMID | 7793929 |
| Pubmed Link | Link |
| Research Link | Link |
| Author | Yamada et al., 1998 |
| Title | Two nearly identical aromatic compound hydrolase genes in a strong polychlorinated biphenyl degrader, Rhodococcus sp. strain RHA1 |
| PMID | 9603807 |
| Pubmed Link | Link |
| Research Link | Link |
| Author | Yang et al., 2007 |
| Title | Characterization and functional analysis of a novel gene cluster involved in biphenyl degradation in Rhodococcus sp. strain R04 |
| PMID | 18045404 |
| Pubmed Link | Link |
| Research Link | Link |
| Author | Masai et al., 1997 |
| Title | The bphDEF meta-cleavage pathway genes involved in biphenyl/polychlorinated biphenyl degradation are located on a linear plasmid and separated from the initial bphACB genes in Rhodococcus sp. strain RHA1 |
| PMID | 9073078 |
| Pubmed Link | Link |
| Research Link | Link |