| Enzyme name | pentachlorophenol-4-monooxygenase |
| Description | Dechlorination of pentachlorophenol to tetrachlorobenzoquinone. Removes also hydrogen and nitro, amino, and cyano groups from benzene ring at the para position in relation to the hydroxyl of phenol. |
| Synonyms |
PCP-4-monooxygenase (PcpB) PcpB pentachlorophenol dehalogenase pentachlorophenol monooxygenase PCP hydroxylase pentachlorophenol-4-monooxygenase pentachlorophenol dechlorinase PCB 4-monooxygenase |
| Degradation pathway |
Hexachlorobenzene biodegradation Pentachlorobenzene biodegradation Pentachlorophenol biodegradation |
| Reaction catalyzed by enzyme |
pentachlorophenol + NADPH + H+ + O2 <=> 2,3,5,6-tetrachloro-1,4-benzoquinone + NADP+ + chloride + H2O |
| Enzyme class | Oxidoreductases |
| BRENDA | EC 1.14.13.50 |
| KEGG Orthology ID | K03391 |
| expasy | EC 1.14.13.50 |
| Enzyme Database | EC 1.14.13.50 |
| Organism |
Sphingobium sp. K74 |
| Status |
Unreviewed |
| Encoding gene | pcpB |
| Gene cluster | pcpABCDE |
| subnit |
N/A |
| Protein Name |
pentachlorophenol-4-monooxygenase |
| GenBank ID |
AJ437487.1 |
| Protein ID |
CAD26734.1 |
| UniProtKB ID |
Q8L1E7 |
| Author | Tiirola et al., 2002 |
| Title | Evidence for natural horizontal transfer of the pcpB gene in the evolution of polychlorophenol-degrading sphingomonads |
| PMID | 12200305.0 |
| Pubmed Link | Link |
| Research Link | Link |
| Author | Lange et al., 1996 |
| Title | Verification of the role of PCP 4-monooxygenase in chlorine elimination from pentachlorophenol by Flavobacterium sp. strain ATCC 39723. |
| PMID | 8619798.0 |
| Pubmed Link | Link |
| Research Link | Link |
| Author | Nakamura et al., 2004 |
| Title | Identification, characterization, and site-directed mutagenesis of recombinant pentachlorophenol 4-monooxygenase. |
| PMID | 15262224.0 |
| Pubmed Link | Link |
| Research Link | Link |
| Author | Rudolph et al., 2014 |
| Title | A radical intermediate in the conversion of pentachlorophenol to tetrachlorohydroquinone by Sphingobium chlorophenolicum. |
| PMID | 25238136.0 |
| Pubmed Link | Link |
| Research Link | Link |