| Enzyme name | Hydroquinone 1,2-dioxygenase |
| Description | Cleaves aromatic rings with two hydroxyl groups at para positions with consumption of O2. Catalyzes the cleavage of chlorohydroquinone (CHQ), as part of the gamma-hexachlorocyclohexane (gamma-HCH or lindane) degradation pathway, producing 5-chlorocarbonyl-4-hydroxy-penta-2,4-dienoate as an intermediate product that can react with water yielding maleylacetate. |
| Synonyms |
hydroquinone dioxygenase hydroquinone 1,2-dioxygenase LinE two-subunit hydroquinone 1,2-dioxygenase |
| Degradation pathway |
Alpha-hexachlorocyclohexane degradation Beta-hexachlorocyclohexane degradation Delta-hexachlorocyclohexane degradation Gamma-hexachlorocyclohexane degradation |
| Reaction catalyzed by enzyme |
chlorohydroquinone (CHQ) + molecular oxygen <=> 5-chlorocarbonyl-4-hydroxy-penta-2,4-dienate + Hydrogen ions |
| Enzyme class | Oxidoreductases |
| BRENDA | EC 1.13.11.66 |
| KEGG Orthology ID | K15240 |
| expasy | EC 1.13.11.66 |
| Enzyme Database | EC 1.13.11.66 |
| Organism |
Sphingobium japonicum |
| Status |
Reviewed |
| Encoding gene | LinE |
| Gene cluster | LinABCDEFGHJ |
| subnit |
linE |
| Protein Name |
Chlorohydroquinone/hydroquinone 1,2-dioxygenase |
| GenBank ID |
AB021867.1 |
| Protein ID |
BAA76672.1 |
| UniProtKB ID |
Q9WXE6 |
| Author | Miyauchi et al., 1999 |
| Title | Cloning and sequencing of a novel meta-cleavage dioxygenase gene whose product is involved in degradation of gamma-hexachlorocyclohexane in Sphingomonas paucimobilis |
| PMID | 10542173.0 |
| Pubmed Link | Link |
| Research Link | Link |
| Author | Miyauchi et al., 1998 |
| Title | Cloning and sequencing of a 2,5-dichlorohydroquinone reductive dehalogenase gene whose product is involved in degradation of gamma-hexachlorocyclohexane by Sphingomonas paucimobilis |
| PMID | 9515900.0 |
| Pubmed Link | Link |
| Research Link | Link |
| Author | Nagata et al., 1994 |
| Title | Cloning and sequencing of a 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase gene involved in the degradation of gamma-hexachlorocyclohexane in Pseudomonas paucimobilis |
| PMID | 7515041.0 |
| Pubmed Link | Link |
| Research Link | Link |
| Author | Zhang and Ciao. 2009 |
| Title | Isolation of Hexachlorocyclohexane-Degrading Sphingomonas sp. and Characterization of Lin Genes Responsible for the Biodegradation of Hexachlorocyclohexane |
| PMID | 18042212.0 |
| Pubmed Link | Link |
| Research Link | Link |