| Enzyme name | Gamma hexachlorocyclohexane dehydrochlorinase 2 |
| Description | Catalyzes the conversion of the important environmental pollutant gamma-hexachlorocyclohexane (gamma-HCH or lindane) to 1,3,4,6-tetrachloro-1,4-cyclohexadiene (1,4-TCDN) via gamma-pentachlorocyclohexene (gamma-PCCH) |
| Synonyms |
linA2 |
| Degradation pathway |
Polychlorinated dibenzofurans (PCDF) biodegradation |
| Reaction catalyzed by enzyme |
<=>-hexachlorocyclohexane <=> (3R,4S,5S,6R)-pentachlorocyclohexene + chloride + H+ |
| Enzyme class | Lyases |
| BRENDA | EC 4.5.1.B1 |
| KEGG Orthology ID | K15236 |
| expasy | EC 4.5.1.- |
| Enzyme Database | EC 4.5.1.- |
| Organism |
Sphingobium Indicum B90A |
| Status |
Reviewed |
| Encoding gene | linA2 |
| Gene cluster | linAB |
| subnit |
N/A |
| Protein Name |
Gamma hexachlorocyclohexane dehydrochlorinase 2 |
| GenBank ID |
CP013070.1 |
| Protein ID |
BAI96690.1 |
| UniProtKB ID |
P59767 |
| Author | Heeb et al., 2019 |
| Title | Biotransformation of short-chain chlorinated paraffins (SCCPs) with LinA2: A HCH and HBCD converting bacterial dehydrohalogenase |
| PMID | 30965245 |
| Pubmed Link | Link |
| Research Link | Link |
| Author | Kumari et al., 2002 |
| Title | Cloning and characterization of lin genes responsible for the degradation of Hexachlorocyclohexane isomers by Sphingomonas paucimobilis strain B90 |
| PMID | 12450824 |
| Pubmed Link | Link |
| Research Link | Link |
| Author | Anand et al., 2012 |
| Title | Genome sequence of Sphingobium indicum B90A, a hexachlorocyclohexane-degrading bacterium |
| PMID | 22843598 |
| Pubmed Link | Link |
| Research Link | Link |